Linked Life Data

P02768

Source:http://identifiers.org/uniprot/P02768

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. SUBCELLULAR LOCATION: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P02768-1; Sequence=Displayed; Name=2; IsoId=P02768-2; Sequence=VSP_021275; TISSUE SPECIFICITY: Plasma. PTM: Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys- 606. PTM: Glycated in diabetic patients. PTM: Phosphorylation sites are present in the extracelllular medium. PTM: Acetylated on Lys-223 by acetylsalicylic acid. POLYMORPHISM: A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A. DISEASE: Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population. SIMILARITY: Belongs to the ALB/AFP/VDB family. SIMILARITY: Contains 3 albumin domains. CAUTION: A peptide arising from positions 166 to 174 was originally (PubMed:3087352 and PubMed:2437111) termed neurotensin- related peptide (NRP) or kinetensin and was thought to regulates fat digestion, lipid absorption, and blood flow. SEQUENCE CAUTION: Sequence=AAF22034.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAF69644.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAG35503.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=Albumin Website; URL="http://www.albumin.org"; WEB RESOURCE: Name=Wikipedia; Note=Serum albumin entry; URL="http://en.wikipedia.org/wiki/Serum_albumin"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALB"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/alb/"; GENE SYNONYMS:ALB. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 609 AA; 69367 MW; F88FF61DD242E818 CRC64;
biopax3:xref
biopax3:displayName
ALBU_HUMAN
biopax3:name
ALB
biopax3:entityFeature
biopax3:organism
biopax3:sequence
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL
biopax3:standardName
Serum albumin