| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. SUBUNIT: Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. PTM: Phosphorylation sites are present in the extracelllular medium. PTM: O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor). POLYMORPHISM: There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has Met-248/Ser-256. SIMILARITY: Belongs to the fetuin family. SIMILARITY: Contains 2 cystatin fetuin-A-type domains. GENE SYNONYMS:AHSG FETUA. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 367 AA; 39325 MW; 1AAF0C8D6B7E2789 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:349,
urn:biopax:RelationshipXref:NCBI GENE_197,
urn:biopax:RelationshipXref:REFSEQ_NP_001613,
urn:biopax:UnificationXref:UNIPROT_A8K9N6,
urn:biopax:UnificationXref:UNIPROT_B2R7G1,
urn:biopax:UnificationXref:UNIPROT_O14961,
urn:biopax:UnificationXref:UNIPROT_O14962,
urn:biopax:UnificationXref:UNIPROT_P02765,
urn:biopax:UnificationXref:UNIPROT_Q9P152
|
| biopax3:displayName |
FETUA_HUMAN
|
| biopax3:name |
AHSG,
Alpha-2-HS-glycoprotein chain A,
Alpha-2-HS-glycoprotein chain B,
Alpha-2-Z-globulin,
Ba-alpha-2-glycoprotein,
Fetuin-A
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLKLDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGGAEVAVTCTVFQTQPVTSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVLLAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPGRIRHFKV
|
| biopax3:standardName |
Alpha-2-HS-glycoprotein
|