| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Involved in the presentation of foreign antigens to the immune system. SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity). Interacts with HTLV-1 accessory protein p12I. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. PTM: Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity). POLYMORPHISM: The following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06 (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02. SIMILARITY: Belongs to the MHC class I family. SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like) domain. GENE SYNONYMS:HLA-B HLAB. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 362 AA; 40460 MW; 5E5A7BDE031403D6 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:4932,
urn:biopax:RelationshipXref:NCBI GENE_3106,
urn:biopax:RelationshipXref:REFSEQ_NP_005505,
urn:biopax:UnificationXref:UNIPROT_P01889,
urn:biopax:UnificationXref:UNIPROT_Q29638,
urn:biopax:UnificationXref:UNIPROT_Q29681,
urn:biopax:UnificationXref:UNIPROT_Q29854,
urn:biopax:UnificationXref:UNIPROT_Q29861,
urn:biopax:UnificationXref:UNIPROT_Q31613,
urn:biopax:UnificationXref:UNIPROT_Q5SRJ2,
urn:biopax:UnificationXref:UNIPROT_Q9GIX1,
urn:biopax:UnificationXref:UNIPROT_Q9TP95
|
| biopax3:displayName |
1B07_HUMAN
|
| biopax3:name |
HLA-B,
MHC class I antigen B*7
|
| biopax3:organism | |
| biopax3:sequence |
MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA
|
| biopax3:standardName |
HLA class I histocompatibility antigen, B-7 alpha chain
|