| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). FUNCTION: Leumorphin has a typical opiod activity and may have anti-apoptotic effect (By similarity). SUBCELLULAR LOCATION: Secreted. PTM: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. DISEASE: Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. SIMILARITY: Belongs to the opioid neuropeptide precursor family. GENE SYNONYMS:PDYN. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 254 AA; 28385 MW; 783E7D6AC068CE68 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:8820,
urn:biopax:RelationshipXref:NCBI GENE_5173,
urn:biopax:RelationshipXref:REFSEQ_NP_001177821,
urn:biopax:RelationshipXref:REFSEQ_NP_001177827,
urn:biopax:RelationshipXref:REFSEQ_NP_001177828,
urn:biopax:RelationshipXref:REFSEQ_NP_001177829,
urn:biopax:RelationshipXref:REFSEQ_NP_077722,
urn:biopax:UnificationXref:UNIPROT_A8K0Q3,
urn:biopax:UnificationXref:UNIPROT_P01213
|
| biopax3:displayName |
PDYN_HUMAN
|
| biopax3:name |
Alpha-neoendorphin,
Beta-neoendorphin,
Beta-neoendorphin-dynorphin,
Big Dyn,
Big dynorphin,
Dyn-A17,
Dyn-B,
Dynorphin A,
Dynorphin A(1-13),
Dynorphin A(1-17),
Dynorphin A(1-8),
Dynorphin B,
Dynorphin B(1-13),
Dynorphin B-29,
Leu-enkephalin,
Leumorphin,
PDYN,
Preprodynorphin,
Rimorphin
|
| biopax3:organism | |
| biopax3:sequence |
MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA
|
| biopax3:standardName |
Proenkephalin-B
|