| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. SUBCELLULAR LOCATION: Secreted. PTM: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. SIMILARITY: Belongs to the opioid neuropeptide precursor family. GENE SYNONYMS:PENK. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 267 AA; 30787 MW; 4189BA600C3FC8EE CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:8831,
urn:biopax:RelationshipXref:NCBI GENE_5179,
urn:biopax:RelationshipXref:REFSEQ_NP_001129162,
urn:biopax:RelationshipXref:REFSEQ_NP_006202,
urn:biopax:UnificationXref:UNIPROT_B2RC23,
urn:biopax:UnificationXref:UNIPROT_P01210,
urn:biopax:UnificationXref:UNIPROT_Q6FHC6,
urn:biopax:UnificationXref:UNIPROT_Q6FHE6
|
| biopax3:displayName |
PENK_HUMAN
|
| biopax3:name |
Leu-enkephalin,
Met-enkephalin,
Met-enkephalin-Arg-Gly-Leu,
Met-enkephalin-Arg-Phe,
OGF,
Opioid growth factor,
PENK,
PENK(114-133),
PENK(143-183),
PENK(237-258),
Synenkephalin
|
| biopax3:organism | |
| biopax3:sequence |
MARFLTLCTWLLLLGPGLLATVRAECSQDCATCSYRLVRPADINFLACVMECEGKLPSLKIWETCKELLQLSKPELPQDGTSTLRENSKPEESHLLAKRYGGFMKRYGGFMKKMDELYPMEPEEEANGSEILAKRYGGFMKKDAEEDDSLANSSDLLKELLETGDNRERSHHQDGSDNEEEVSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEALPSDEEGESYSKEVPEMEKRYGGFMRF
|
| biopax3:standardName |
Proenkephalin-A
|