P01106

FUNCTION: Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2 (By similarity). Interacts with NO66. SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Nucleus, nucleolus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P01106-1; Sequence=Displayed; Name=2; IsoId=P01106-2; Sequence=VSP_037813; Note=Initiates from CTG codon. Ref.7 (BAA01374) sequence is in conflict in positions: 2:D->N, 6:V->E; PTM: Phosphorylated by PRKDC. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. PTM: Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. DISEASE: Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. DISEASE: Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. DISEASE: Defects in MYC are a cause of Burkitt lymphoma (BL) [MIM:113970]. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci. BIOTECHNOLOGY: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes. SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MYCID27.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/myc/"; WEB RESOURCE: Name=Wikipedia; Note=Myc entry; URL="http://en.wikipedia.org/wiki/Myc"; GENE SYNONYMS:MYC BHLHE39. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 439 AA; 48804 MW; ED5C028029A4C5D1 CRC64;

MYC_HUMAN

urn:biopax:ModificationFeature:MYC_HUMAN_1, urn:biopax:ModificationFeature:MYC_HUMAN_10, urn:biopax:ModificationFeature:MYC_HUMAN_11, urn:biopax:ModificationFeature:MYC_HUMAN_12, urn:biopax:ModificationFeature:MYC_HUMAN_13, urn:biopax:ModificationFeature:MYC_HUMAN_14, urn:biopax:ModificationFeature:MYC_HUMAN_15, urn:biopax:ModificationFeature:MYC_HUMAN_2, urn:biopax:ModificationFeature:MYC_HUMAN_3, urn:biopax:ModificationFeature:MYC_HUMAN_4, urn:biopax:ModificationFeature:MYC_HUMAN_5, urn:biopax:ModificationFeature:MYC_HUMAN_6, urn:biopax:ModificationFeature:MYC_HUMAN_7, urn:biopax:ModificationFeature:MYC_HUMAN_8, urn:biopax:ModificationFeature:MYC_HUMAN_9

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