| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Kininogens are plasma glycoproteins with a number of functions: (1) as precursor of the active peptide bradykinin they effect smooth muscle contraction, induction of hypotension and increase of vascular permeability. (2) They play a role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII. (3) They are inhibitor of thiol proteases. SUBCELLULAR LOCATION: Secreted, extracellular space. TISSUE SPECIFICITY: Plasma. INDUCTION: In response to an inflammatory stimulant. T-kininogen II synthesis is induced and the plasma concentration of T- kininogen I is raised. PTM: As T-kinin is preceded by a Met instead of an Arg or Lys, it is not released from its precursor by either tissue or plasma kallikrein. MISCELLANEOUS: Rats express four types of kininogens: the classical HMW and LMW kininogens produced by alternative splicing of the same gene, and two additional LMW-like kininogens: T-I and T-II. SIMILARITY: Contains 3 cystatin domains. GENE SYNONYMS:Map1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 430 AA; 47775 MW; FEBBF28FA44793C3 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
KNT1_RAT
|
| biopax3:name |
Alpha-1-MAP,
Major acute phase protein,
Map1,
T-kinin,
T-kininogen 1 heavy chain,
T-kininogen 1 light chain,
T-kininogen I,
T-kininogen I heavy chain,
T-kininogen I light chain,
Thiostatin
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MKLITILLLCSRLLPSLAQEEGAQELNCNDETVFQAVDTALKKYNAELESGNQFVLYRVTEGTKKDGAETLYSFKYQIKEGNCSVQSGLTWQDCDFKDAEEAATGECTTTLGKKENKFSVATQICNITPGKGPKKTEEDLCVGCFQPIPMDSSDLKPVLKHAVEHFNNNTKHTHLFALREVKSAHSQVVAGMNYKIIYSIVQTNCSKEDFPSLREDCVPLPYGDHGECTGHTHVDIHNTIAGFSQSCDLYPGDDLFELLPKNCRGCPREIPVDSPELKEALGHSIAQLNAQHNHIFYFKIDTVKKATSQVVAGVIYVIEFIARETNCSKQSKTELTADCETKHLGQSLNCNANVYMRPWENKVVPTVRCQALDMMISRPPGFSPFRLVRVQETKEGTTRLLNSCEYKGRLSKARAGPAPDHQAEASTVTP
|
| biopax3:standardName |
T-kininogen 1
|