| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart. SUBUNIT: Interacts with PTPN6 and PTPN11. Binds to heparin. SUBCELLULAR LOCATION: Isoform E: Endoplasmic reticulum. Golgi apparatus. SUBCELLULAR LOCATION: Isoform D: Endoplasmic reticulum. Golgi apparatus. SUBCELLULAR LOCATION: Isoform B: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform A: Cell membrane; Single-pass type I membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=7; Name=B; IsoId=O95866-1; Sequence=Displayed; Name=A; IsoId=O95866-2; Sequence=VSP_014176; Name=C; IsoId=O95866-3; Sequence=VSP_014174; Name=D; IsoId=O95866-4; Sequence=VSP_014172; Name=E; IsoId=O95866-5; Sequence=VSP_014173; Name=F; IsoId=O95866-6; Sequence=VSP_014175; Name=G; IsoId=O95866-7; Sequence=VSP_014177; TISSUE SPECIFICITY: Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. Expressed in platelets. PTM: All isoforms are N-glycosylated. PTM: Isoform E is O-glycosylated. GENE SYNONYMS:G6B C6orf25. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 241 AA; 26163 MW; C1390699EAA109BD CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:13937,
urn:biopax:RelationshipXref:NCBI GENE_80739,
urn:biopax:RelationshipXref:REFSEQ_NP_079536,
urn:biopax:RelationshipXref:REFSEQ_NP_612116,
urn:biopax:RelationshipXref:REFSEQ_NP_612117,
urn:biopax:RelationshipXref:REFSEQ_NP_612118,
urn:biopax:RelationshipXref:REFSEQ_NP_612119,
urn:biopax:RelationshipXref:REFSEQ_NP_612121,
urn:biopax:UnificationXref:UNIPROT_A2BEZ1,
urn:biopax:UnificationXref:UNIPROT_A2BEZ2,
urn:biopax:UnificationXref:UNIPROT_A2BEZ3,
urn:biopax:UnificationXref:UNIPROT_A2BEZ4,
urn:biopax:UnificationXref:UNIPROT_A2BEZ5,
urn:biopax:UnificationXref:UNIPROT_B0UXC4,
urn:biopax:UnificationXref:UNIPROT_B0UXC7,
urn:biopax:UnificationXref:UNIPROT_B0UXC8,
urn:biopax:UnificationXref:UNIPROT_B0V024,
urn:biopax:UnificationXref:UNIPROT_B0V026,
urn:biopax:UnificationXref:UNIPROT_O95866,
urn:biopax:UnificationXref:UNIPROT_Q14CK2,
urn:biopax:UnificationXref:UNIPROT_Q96A86,
urn:biopax:UnificationXref:UNIPROT_Q96A87,
urn:biopax:UnificationXref:UNIPROT_Q96A88,
urn:biopax:UnificationXref:UNIPROT_Q96A89,
urn:biopax:UnificationXref:UNIPROT_Q96A90,
urn:biopax:UnificationXref:UNIPROT_Q96A91
|
| biopax3:displayName |
G6B_HUMAN
|
| biopax3:name |
G6B
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MAVFLQLLPLLLSRAQGNPGASLDGRPGDRVNLSCGGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDSGIRRLELLLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKAPGPTHGSVYPQLLIPLLGAGLVLGLGALGLVWWLHRRLPPQPIRPLPRFAPLVKTEPQRPVKEEEPKIPGDLDQEPSLLYADLDHLALSRPRRLSTADPADASTIYAVVV
|
| biopax3:standardName |
Protein G6b
|