| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. SUBUNIT: Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Isoform 2 interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN. SUBCELLULAR LOCATION: Isoform 1: Secreted. SUBCELLULAR LOCATION: Isoform 2: Nucleus. Note=Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initation at Met-27 according to (PubMed:16150905). ALTERNATIVE PRODUCTS: Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=O95633-1; Sequence=Displayed; Name=2; IsoId=O95633-2; Sequence=VSP_038553; TISSUE SPECIFICITY: Expressed in a wide range of tissues. DISEASE: Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. SIMILARITY: Contains 2 follistatin-like domains. SIMILARITY: Contains 2 Kazal-like domains. SIMILARITY: Contains 1 TB (TGF-beta binding) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FSTL3ID111ch19p13.html"; GENE SYNONYMS:FSTL3 FLRG. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 263 AA; 27663 MW; 6A9AB86ADD4FD09C CRC64;
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| biopax3:xref | |
| biopax3:displayName |
FSTL3_HUMAN
|
| biopax3:name |
FSTL3,
Follistatin-like protein 3,
Follistatin-related gene protein
|
| biopax3:organism | |
| biopax3:sequence |
MRPGAPGPLWPLPWGALAWAVGFVSSMGSGNPAPGGVCWLQQGQEATCSLVLQTDVTRAECCASGNIDTAWSNLTHPGNKINLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPRCECAPDCSGLPARLQVCGSDGATYRDECELRAARCRGHPDLSVMYRGRCRKSCEHVVCPRPQSCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTYISSCHMRQATCFLGRSIGVRHAGSCAGTPEEPPGGESAEEEENFV
|
| biopax3:standardName |
Follistatin-related protein 3
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