| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'- phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation. COFACTOR: Magnesium (Probable). SUBUNIT: Interacts with TRAF2, TRAF3, TRAF5, TRAF6, TNFRSF8/CD30, TNFRSF5/CD40, TNFRSF1B/TNF-R75, ETS1, ETS2, FLI1, SMAD3 and ACVR1B/ALK4. SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O95551-1; Sequence=Displayed; Name=2; IsoId=O95551-2; Sequence=VSP_038523; Note=No experimental confirmation available; Name=3; IsoId=O95551-3; Sequence=VSP_038524; Note=No experimental confirmation available; TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Belongs to the CCR4/nocturin family. SEQUENCE CAUTION: Sequence=BAG59230.1; Type=Erroneous initiation; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ttrap/"; GENE SYNONYMS:TDP2 EAP2 TTRAP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 362 AA; 40930 MW; 37892E125DB64410 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:17768,
urn:biopax:RelationshipXref:NCBI GENE_51567,
urn:biopax:RelationshipXref:REFSEQ_NP_057698,
urn:biopax:UnificationXref:UNIPROT_B4DKL8,
urn:biopax:UnificationXref:UNIPROT_B4DQ95,
urn:biopax:UnificationXref:UNIPROT_O95551,
urn:biopax:UnificationXref:UNIPROT_Q2TBE2,
urn:biopax:UnificationXref:UNIPROT_Q5JYM0,
urn:biopax:UnificationXref:UNIPROT_Q7Z6U5,
urn:biopax:UnificationXref:UNIPROT_Q9NUK5,
urn:biopax:UnificationXref:UNIPROT_Q9NYY9
|
| biopax3:displayName |
TYDP2_HUMAN
|
| biopax3:name |
3.1.4.-,
5'-Tyr-DNA phosphodiesterase,
5'-tyrosyl-DNA phosphodiesterase,
EAPII,
ETS1-associated protein 2,
ETS1-associated protein II,
TDP2,
TRAF and TNF receptor-associated protein,
Tyr-DNA phosphodiesterase 2
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNSYFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQLKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQMNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDIIL
|
| biopax3:standardName |
Tyrosyl-DNA phosphodiesterase 2
|