| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity). SUBUNIT: Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85) (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=O95490-1; Sequence=Displayed; Name=2; Synonyms=Lectomedin-1 gamma; IsoId=O95490-2; Sequence=VSP_010104, VSP_010107; Name=3; Synonyms=Lectomedin-1 beta; IsoId=O95490-3; Sequence=VSP_010104, VSP_010105, VSP_010106; Name=4; Synonyms=Lectomedin-1 alpha; IsoId=O95490-4; Sequence=VSP_010104, VSP_010107, VSP_010108, VSP_010109; Name=5; IsoId=O95490-5; Sequence=VSP_010107; Note=No experimental confirmation; Name=6; IsoId=O95490-6; Sequence=VSP_042267; Name=7; IsoId=O95490-7; Sequence=VSP_010104, VSP_042267; Note=No experimental confirmation; TISSUE SPECIFICITY: Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others. PTM: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit (By similarity). SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. SIMILARITY: Contains 1 GPS domain. SIMILARITY: Contains 1 olfactomedin-like domain. SIMILARITY: Contains 1 SUEL-type lectin domain. SEQUENCE CAUTION: Sequence=CAI22406.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LPHH1ID313.html"; GENE SYNONYMS:LPHN2 KIAA0786 LEC1 LPHH1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1459 AA; 163349 MW; 30707B7C3C069029 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:18582,
urn:biopax:RelationshipXref:NCBI GENE_23266,
urn:biopax:RelationshipXref:REFSEQ_NP_036434,
urn:biopax:UnificationXref:UNIPROT_A5XEI2,
urn:biopax:UnificationXref:UNIPROT_B1ALT8,
urn:biopax:UnificationXref:UNIPROT_B1ALT9,
urn:biopax:UnificationXref:UNIPROT_B1ALU0,
urn:biopax:UnificationXref:UNIPROT_B1ALU2,
urn:biopax:UnificationXref:UNIPROT_B1ALU4,
urn:biopax:UnificationXref:UNIPROT_B1ALU5,
urn:biopax:UnificationXref:UNIPROT_B1ALU6,
urn:biopax:UnificationXref:UNIPROT_O94882,
urn:biopax:UnificationXref:UNIPROT_O95490,
urn:biopax:UnificationXref:UNIPROT_Q5VX76,
urn:biopax:UnificationXref:UNIPROT_Q9UKY5,
urn:biopax:UnificationXref:UNIPROT_Q9UKY6
|
| biopax3:displayName |
LPHN2_HUMAN
|
| biopax3:name |
CIRL-2,
Calcium-independent alpha-latrotoxin receptor 2,
LPHN2,
Latrophilin homolog 1,
Lectomedin-1
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTYKYLEVQYECVPYIFVCPGTLKAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRTDTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKSGEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEATWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNRGEYVDVPFPNQYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIISTTSTTSQKGPMSTTVAGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWPQTQRGMMVERPCPKGTRGTASYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAASLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREKTCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTRVSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLSANTVKQNSRNGLAKLVFIIYRSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVLFTLPHIDPDNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFIFIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAPSAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDCGLSLNDTAFEKMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMHSDNPGLELHHKELEAPLIPQRTHSLLYQPQKKVKSEGTDSYVSQLTAEAEDHLQSPNRDSLYTSMPNLRDSPYPESSPDMEEDLSPSRRSENEDIYYKSMPNLGAGHQLQMCYQISRGNSDGYIIPINKEGCIPEGDVREGQMQLVTSL
|
| biopax3:standardName |
Latrophilin-2
|