| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. SUBUNIT: Monomer (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha- tocopherol. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O76054-1; Sequence=Displayed; Name=2; IsoId=O76054-4; Sequence=VSP_042021; Note=No experimental confirmation available; TISSUE SPECIFICITY: Widely expressed. Strong expression in liver, brain and prostate. DEVELOPMENTAL STAGE: Low expression in fetal tissues. SIMILARITY: Contains 1 CRAL-TRIO domain. SIMILARITY: Contains 1 GOLD domain. SEQUENCE CAUTION: Sequence=BAA86500.2; Type=Erroneous initiation; GENE SYNONYMS:SEC14L2 C22orf6 KIAA1186 KIAA1658. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 403 AA; 46145 MW; D846747EC8D1513E CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:10699,
urn:biopax:RelationshipXref:NCBI GENE_23541,
urn:biopax:RelationshipXref:REFSEQ_NP_001191133,
urn:biopax:RelationshipXref:REFSEQ_NP_036561,
urn:biopax:RelationshipXref:REFSEQ_NP_203740,
urn:biopax:UnificationXref:UNIPROT_O76054,
urn:biopax:UnificationXref:UNIPROT_Q53EQ2,
urn:biopax:UnificationXref:UNIPROT_Q6PD61,
urn:biopax:UnificationXref:UNIPROT_Q9ULN4
|
| biopax3:displayName |
S14L2_HUMAN
|
| biopax3:name |
Alpha-tocopherol-associated protein,
SEC14L2,
SPF,
Squalene transfer protein,
Supernatant protein factor,
TAP,
hTAP
|
| biopax3:organism | |
| biopax3:sequence |
MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDGTLTCSDPGIYVLRFDNTYSFIHAKKVNFTVEVLLPDKASEEKMKQLGAGTPK
|
| biopax3:standardName |
SEC14-like protein 2
|