| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with RB1 and WAC. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75150-1; Sequence=Displayed; Name=3; IsoId=O75150-3; Sequence=VSP_016682, VSP_016683; Note=No experimental confirmation available; Name=4; IsoId=O75150-4; Sequence=VSP_016681; Note=No experimental confirmation available; TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine. SIMILARITY: Belongs to the BRE1 family. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=BAA31636.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAE45869.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; GENE SYNONYMS:RNF40 BRE1B KIAA0661. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1001 AA; 113650 MW; 82D7CD183EDD5EFC CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:16867,
urn:biopax:RelationshipXref:NCBI GENE_9810,
urn:biopax:RelationshipXref:REFSEQ_NP_001193962,
urn:biopax:RelationshipXref:REFSEQ_NP_001193963,
urn:biopax:RelationshipXref:REFSEQ_NP_055586,
urn:biopax:UnificationXref:UNIPROT_O75150,
urn:biopax:UnificationXref:UNIPROT_Q6AHZ6,
urn:biopax:UnificationXref:UNIPROT_Q6N005,
urn:biopax:UnificationXref:UNIPROT_Q7L3T6,
urn:biopax:UnificationXref:UNIPROT_Q8N615,
urn:biopax:UnificationXref:UNIPROT_Q96T18,
urn:biopax:UnificationXref:UNIPROT_Q9BSV9,
urn:biopax:UnificationXref:UNIPROT_Q9HC82
|
| biopax3:displayName |
BRE1B_HUMAN
|
| biopax3:name |
6.3.2.-,
95 kDa retinoblastoma-associated protein,
BRE1-B,
RBP95,
RING finger protein 40,
RNF40
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MSGPGNKRAAGDGGSGPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELQEREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRIYIS
|
| biopax3:standardName |
E3 ubiquitin-protein ligase BRE1B
|