Linked Life Data

O75081

Source:http://identifiers.org/uniprot/O75081

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. FUNCTION: Isoform 2 functions as an A-kinase-anchoring protein. SUBUNIT: Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity). Heterodimer with RUNX1T1 and CBFA2T2. Interacts with ERBB4, HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, NCOR1, NCOR2, and ZNF652. According to PubMed:12242670, may not interact with HDAC6. Interacts with PLXNA1, PLXNA3 and PRKAR1A. Isoform 2 interacts with PRKAR2A, PDE7A and probably PDE4A. SUBCELLULAR LOCATION: Isoform 1: Nucleus, nucleolus. Note=The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm. SUBCELLULAR LOCATION: Isoform 2: Nucleus, nucleoplasm. Golgi apparatus membrane. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=CBFA2T3A, MTG16a; IsoId=O75081-1; Sequence=Displayed; Name=2; Synonyms=CBFA2T3B, MTG16b; IsoId=O75081-2; Sequence=VSP_028620, VSP_028624; Name=3; Synonyms=MTG16c; IsoId=O75081-4; Sequence=VSP_028621; Note=No experimental confirmation available; Name=4; Synonyms=MTG16HEL; IsoId=O75081-5; Sequence=VSP_028622, VSP_028623; Note=No experimental confirmation available; TISSUE SPECIFICITY: Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level). INDUCTION: Down-regulated by all-trans retinoic acid (ATRA). DISEASE: Note=A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein. SIMILARITY: Belongs to the CBFA2T family. SIMILARITY: Contains 1 MYND-type zinc finger. SIMILARITY: Contains 1 TAFH (NHR1) domain. SEQUENCE CAUTION: Sequence=AAH62624.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAA31276.1; Type=Erroneous gene model prediction; Sequence=BAA31277.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CBFA2T3ID428ch16q24.html"; GENE SYNONYMS:CBFA2T3 MTG16 MTGR2 ZMYND4. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 653 AA; 71192 MW; 0B72B602120FA5DE CRC64;
biopax3:xref
biopax3:displayName
MTG16_HUMAN
biopax3:name
CBFA2T3, MTG8-related protein 2, Myeloid translocation gene on chromosome 16 protein, Zinc finger MYND domain-containing protein 4, hMTG16
biopax3:entityFeature
biopax3:organism
biopax3:sequence
MPASRLRDRAASSASGSTCGSMSQTHPVLESGLLASAGCSAPRGPRKGGPAPVDRKAKASAMPDSPAEVKTQPRSTPPSMPPPPPAASQGATRPPSFTPHTHREDGPATLPHGRFHGCLKWSMVCLLMNGSSHSPTAINGAPCTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQTPAQYLAQHEQLLLDASASSPIDSSELLLEVNENGKRRTPDRTKENGSDRDPLHPEHLSKRPCTLNPAQRYSPSNGPPQPTPPPHYRLEDIAMAHHFRDAYRHPDPRELRERHRPLVVPGSRQEEVIDHKLTEREWAEEWKHLNNLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWARRYSDAEDTKKGPAPAAARPRSSSAGPEGPQLDVPREFLPRTLTGYVPEDIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELITTERAKMERALAEAKRQASEDALTVINQQEDSSESCWNCGRKASETCSGCNAARYCGSFCQHRDWEKHHHVCGQSLQGPTAVVADPVPGPPEAAHSLGPSLPVGAASPSEAGSAGPSRPGSPSPPGPLDTVPR
biopax3:standardName
Protein CBFA2T3