| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand- induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. SUBUNIT: Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma- catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2. Interacts with NANOS1 (via N-terminal region). Interacts with FER. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=32; Comment=Experimental confirmation may be lacking for some isoforms; Name=1ABC; IsoId=O60716-1; Sequence=Displayed; Name=1AB; IsoId=O60716-2; Sequence=VSP_006743; Name=1AC; IsoId=O60716-3; Sequence=VSP_006745; Name=1BC; IsoId=O60716-4; Sequence=VSP_006744; Name=1A; IsoId=O60716-5; Sequence=VSP_006743, VSP_006745; Name=1B; IsoId=O60716-6; Sequence=VSP_006743, VSP_006744; Name=1C; IsoId=O60716-7; Sequence=VSP_006744, VSP_006745; Name=1; IsoId=O60716-8; Sequence=VSP_006743, VSP_006744, VSP_006745; Name=2ABC; IsoId=O60716-9; Sequence=VSP_006740; Name=2AB; IsoId=O60716-10; Sequence=VSP_006740, VSP_006743; Name=2AC; IsoId=O60716-11; Sequence=VSP_006740, VSP_006745; Name=2BC; IsoId=O60716-12; Sequence=VSP_006740, VSP_006744; Name=2A; IsoId=O60716-13; Sequence=VSP_006740, VSP_006743, VSP_006745; Name=2B; IsoId=O60716-14; Sequence=VSP_006740, VSP_006743, VSP_006744; Name=2C; IsoId=O60716-15; Sequence=VSP_006740, VSP_006744, VSP_006745; Name=2; IsoId=O60716-16; Sequence=VSP_006740, VSP_006743, VSP_006744, VSP_006745; Name=3ABC; IsoId=O60716-17; Sequence=VSP_006741; Name=3AB; IsoId=O60716-18; Sequence=VSP_006741, VSP_006743; Name=3AC; IsoId=O60716-19; Sequence=VSP_006741, VSP_006745; Name=3BC; IsoId=O60716-20; Sequence=VSP_006741, VSP_006744; Name=3A; IsoId=O60716-21; Sequence=VSP_006741, VSP_006743, VSP_006745; Name=3B; IsoId=O60716-22; Sequence=VSP_006741, VSP_006743, VSP_006744; Name=3C; IsoId=O60716-23; Sequence=VSP_006741, VSP_006744, VSP_006745; Name=3; IsoId=O60716-24; Sequence=VSP_006741, VSP_006743, VSP_006744, VSP_006745; Name=4ABC; IsoId=O60716-25; Sequence=VSP_006742; Name=4AB; IsoId=O60716-26; Sequence=VSP_006742, VSP_006743; Name=4AC; IsoId=O60716-27; Sequence=VSP_006742, VSP_006745; Name=4BC; IsoId=O60716-28; Sequence=VSP_006742, VSP_006744; Name=4A; IsoId=O60716-29; Sequence=VSP_006742, VSP_006743, VSP_006745; Name=4B; IsoId=O60716-30; Sequence=VSP_006742, VSP_006743, VSP_006744; Name=4C; IsoId=O60716-31; Sequence=VSP_006742, VSP_006744, VSP_006745; Name=4; IsoId=O60716-32; Sequence=VSP_006742, VSP_006743, VSP_006744, VSP_006745; TISSUE SPECIFICITY: Expressed in vascular endothelium. INDUCTION: Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure. DOMAIN: A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted. PTM: Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ. SIMILARITY: Belongs to the beta-catenin family. SIMILARITY: Contains 10 ARM repeats. SEQUENCE CAUTION: Sequence=BAA20838.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ctnnd1/"; GENE SYNONYMS:CTNND1 KIAA0384. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 968 AA; 108170 MW; D5C37489A891F292 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:2515,
urn:biopax:RelationshipXref:NCBI GENE_1500,
urn:biopax:RelationshipXref:REFSEQ_NP_001078927,
urn:biopax:RelationshipXref:REFSEQ_NP_001078928,
urn:biopax:RelationshipXref:REFSEQ_NP_001078929,
urn:biopax:RelationshipXref:REFSEQ_NP_001078930,
urn:biopax:RelationshipXref:REFSEQ_NP_001078931,
urn:biopax:RelationshipXref:REFSEQ_NP_001078932,
urn:biopax:RelationshipXref:REFSEQ_NP_001078933,
urn:biopax:RelationshipXref:REFSEQ_NP_001078934,
urn:biopax:RelationshipXref:REFSEQ_NP_001078935,
urn:biopax:RelationshipXref:REFSEQ_NP_001078936,
urn:biopax:RelationshipXref:REFSEQ_NP_001078937,
urn:biopax:RelationshipXref:REFSEQ_NP_001078938,
urn:biopax:RelationshipXref:REFSEQ_NP_001193812,
urn:biopax:RelationshipXref:REFSEQ_NP_001193813,
urn:biopax:RelationshipXref:REFSEQ_NP_001193814,
urn:biopax:RelationshipXref:REFSEQ_NP_001193815,
urn:biopax:RelationshipXref:REFSEQ_NP_001193816,
urn:biopax:RelationshipXref:REFSEQ_NP_001193817,
urn:biopax:RelationshipXref:REFSEQ_NP_001193818,
urn:biopax:RelationshipXref:REFSEQ_NP_001193819,
urn:biopax:RelationshipXref:REFSEQ_NP_001193820,
urn:biopax:RelationshipXref:REFSEQ_NP_001322,
urn:biopax:UnificationXref:UNIPROT_A8K939,
urn:biopax:UnificationXref:UNIPROT_O15088,
urn:biopax:UnificationXref:UNIPROT_O60713,
urn:biopax:UnificationXref:UNIPROT_O60714,
urn:biopax:UnificationXref:UNIPROT_O60715,
urn:biopax:UnificationXref:UNIPROT_O60716,
urn:biopax:UnificationXref:UNIPROT_O60935,
urn:biopax:UnificationXref:UNIPROT_Q6DHZ7,
urn:biopax:UnificationXref:UNIPROT_Q6RBX8,
urn:biopax:UnificationXref:UNIPROT_Q9UP71,
urn:biopax:UnificationXref:UNIPROT_Q9UP72,
urn:biopax:UnificationXref:UNIPROT_Q9UP73
|
| biopax3:displayName |
CTND1_HUMAN
|
| biopax3:name |
CAS,
CTNND1,
Cadherin-associated Src substrate,
p120 catenin,
p120(cas),
p120(ctn)
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:CTND1_HUMAN_1,
urn:biopax:ModificationFeature:CTND1_HUMAN_10,
urn:biopax:ModificationFeature:CTND1_HUMAN_11,
urn:biopax:ModificationFeature:CTND1_HUMAN_12,
urn:biopax:ModificationFeature:CTND1_HUMAN_13,
urn:biopax:ModificationFeature:CTND1_HUMAN_14,
urn:biopax:ModificationFeature:CTND1_HUMAN_15,
urn:biopax:ModificationFeature:CTND1_HUMAN_16,
urn:biopax:ModificationFeature:CTND1_HUMAN_17,
urn:biopax:ModificationFeature:CTND1_HUMAN_18,
urn:biopax:ModificationFeature:CTND1_HUMAN_19,
urn:biopax:ModificationFeature:CTND1_HUMAN_2,
urn:biopax:ModificationFeature:CTND1_HUMAN_20,
urn:biopax:ModificationFeature:CTND1_HUMAN_21,
urn:biopax:ModificationFeature:CTND1_HUMAN_22,
urn:biopax:ModificationFeature:CTND1_HUMAN_23,
urn:biopax:ModificationFeature:CTND1_HUMAN_24,
urn:biopax:ModificationFeature:CTND1_HUMAN_25,
urn:biopax:ModificationFeature:CTND1_HUMAN_26,
urn:biopax:ModificationFeature:CTND1_HUMAN_27,
urn:biopax:ModificationFeature:CTND1_HUMAN_28,
urn:biopax:ModificationFeature:CTND1_HUMAN_29,
urn:biopax:ModificationFeature:CTND1_HUMAN_3,
urn:biopax:ModificationFeature:CTND1_HUMAN_30,
urn:biopax:ModificationFeature:CTND1_HUMAN_31,
urn:biopax:ModificationFeature:CTND1_HUMAN_32,
urn:biopax:ModificationFeature:CTND1_HUMAN_33,
urn:biopax:ModificationFeature:CTND1_HUMAN_34,
urn:biopax:ModificationFeature:CTND1_HUMAN_35,
urn:biopax:ModificationFeature:CTND1_HUMAN_36,
urn:biopax:ModificationFeature:CTND1_HUMAN_4,
urn:biopax:ModificationFeature:CTND1_HUMAN_5,
urn:biopax:ModificationFeature:CTND1_HUMAN_6,
urn:biopax:ModificationFeature:CTND1_HUMAN_7,
urn:biopax:ModificationFeature:CTND1_HUMAN_8,
urn:biopax:ModificationFeature:CTND1_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGPDGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQDEGQESLEEELDVLVLDDEGGQVSYPSMQKI
|
| biopax3:standardName |
Catenin delta-1
|