| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. SUBUNIT: Binds the second PAH repeat of SIN3A (By similarity). Binds TCF4 and RB1. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O60381-1; Sequence=Displayed; Name=2; IsoId=O60381-2; Sequence=VSP_014655; Note=No experimental confirmation available; Name=3; IsoId=O60381-3; Sequence=VSP_014656; SIMILARITY: Contains 1 AXH domain. SIMILARITY: Contains 1 HMG box DNA-binding domain. SEQUENCE CAUTION: Sequence=BAB85059.1; Type=Erroneous initiation; GENE SYNONYMS:HBP1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 514 AA; 57645 MW; 2AFADC995F73A031 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:23200,
urn:biopax:RelationshipXref:NCBI GENE_26959,
urn:biopax:RelationshipXref:REFSEQ_NP_001231191,
urn:biopax:RelationshipXref:REFSEQ_NP_036389,
urn:biopax:UnificationXref:UNIPROT_B3KVB7,
urn:biopax:UnificationXref:UNIPROT_O60381,
urn:biopax:UnificationXref:UNIPROT_Q8TBM1,
urn:biopax:UnificationXref:UNIPROT_Q8TE93,
urn:biopax:UnificationXref:UNIPROT_Q96AJ2
|
| biopax3:displayName |
HBP1_HUMAN
|
| biopax3:name |
HBP1,
HMG box transcription factor 1,
High mobility group box transcription factor 1
|
| biopax3:organism | |
| biopax3:sequence |
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGTRLCFHKGSNKEWQDVEDFARAEGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEVHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGPGGQDFARSGFSKNCGSPGSSQLSSNSLYAKAVKNHSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH
|
| biopax3:standardName |
HMG box-containing protein 1
|