| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK. SUBUNIT: Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=C6ORF4; IsoId=O43734-1; Sequence=Displayed; Name=2; Synonyms=C6ORF5, C6ORF6; IsoId=O43734-2; Sequence=VSP_004163; Name=3; IsoId=O43734-3; Sequence=VSP_035733; Name=4; IsoId=O43734-4; Sequence=VSP_040374; TISSUE SPECIFICITY: Widely expressed. DISEASE: Defects in TRAF3IP2 are the cause of susceptibility to psoriasis type 13 (PSORS13) [MIM:614070]. PSORS13 is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. SIMILARITY: Contains 1 SEFIR domain. SEQUENCE CAUTION: Sequence=BAB15507.1; Type=Erroneous initiation; Note=Translation N-terminally extended; GENE SYNONYMS:TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 574 AA; 64666 MW; 4985795466D71422 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:1343,
urn:biopax:RelationshipXref:NCBI GENE_10758,
urn:biopax:RelationshipXref:REFSEQ_NP_001157753,
urn:biopax:RelationshipXref:REFSEQ_NP_001157755,
urn:biopax:RelationshipXref:REFSEQ_NP_679211,
urn:biopax:UnificationXref:UNIPROT_B2RAY9,
urn:biopax:UnificationXref:UNIPROT_E1P555,
urn:biopax:UnificationXref:UNIPROT_O43734,
urn:biopax:UnificationXref:UNIPROT_Q5R3A3,
urn:biopax:UnificationXref:UNIPROT_Q7Z6Q2,
urn:biopax:UnificationXref:UNIPROT_Q7Z6Q3,
urn:biopax:UnificationXref:UNIPROT_Q9H5W2,
urn:biopax:UnificationXref:UNIPROT_Q9H6Y3,
urn:biopax:UnificationXref:UNIPROT_Q9NS14,
urn:biopax:UnificationXref:UNIPROT_Q9UG72
|
| biopax3:displayName |
CIKS_HUMAN
|
| biopax3:name |
ACT1,
Connection to IKK and SAPK/JNK,
Nuclear factor NF-kappa-B activator 1,
TRAF3-interacting protein 2,
TRAF3IP2
|
| biopax3:organism | |
| biopax3:sequence |
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVTCLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSLGGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPWNYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNRAGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGIDIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMMQIEFIKQGSMNFRFIPVLFPNAKKEHVPTWLQNTHVYSWPKNKKNILLRLLREEEYVAPPRGPLPTLQVVPL
|
| biopax3:standardName |
Adapter protein CIKS
|