| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. SUBUNIT: Interacts with NEDD4L (By similarity). Interacts with WWP1 (By similarity). Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=A; IsoId=O43541-1; Sequence=Displayed; Name=B; Synonyms=Smad 6S; IsoId=O43541-2; Sequence=VSP_006179, VSP_006180; Name=D; IsoId=O43541-4; Sequence=VSP_035489, VSP_035490; TISSUE SPECIFICITY: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. PTM: Phosphorylated by BMP type 1 receptor kinase and by PRKX. PTM: Ubiquitinated by WWP1 (By similarity). DISEASE: Note=Genetic variations in SMAD6 may contribute to increased risk of congenital cardiovascular malformations (CVM). CVM is a major cause of mortality and morbidity in childhood. In most sporadic cases that cannot be attributed to particular malformation syndromes or teratogenic exposures, there remains a substantial excess familial risk, indicating a significant genetic contribution to disease susceptibility (PubMed:22275001). SIMILARITY: Belongs to the dwarfin/SMAD family. SIMILARITY: Contains 1 MH1 (MAD homology 1) domain. SIMILARITY: Contains 1 MH2 (MAD homology 2) domain. GENE SYNONYMS:SMAD6 MADH6. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 496 AA; 53497 MW; A4B928AE2D34EBC2 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:6772,
urn:biopax:RelationshipXref:NCBI GENE_4091,
urn:biopax:RelationshipXref:REFSEQ_NP_001136333,
urn:biopax:RelationshipXref:REFSEQ_NP_005576,
urn:biopax:UnificationXref:UNIPROT_A9J6M5,
urn:biopax:UnificationXref:UNIPROT_O43541,
urn:biopax:UnificationXref:UNIPROT_O43654,
urn:biopax:UnificationXref:UNIPROT_Q15799,
urn:biopax:UnificationXref:UNIPROT_Q7Z7L4,
urn:biopax:UnificationXref:UNIPROT_Q96E31,
urn:biopax:UnificationXref:UNIPROT_Q9UKZ3
|
| biopax3:displayName |
SMAD6_HUMAN
|
| biopax3:name |
MAD homolog 6,
Mothers against DPP homolog 6,
SMAD 6,
SMAD family member 6,
SMAD6,
Smad6,
hSMAD6
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEVRPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR
|
| biopax3:standardName |
Mothers against decapentaplegic homolog 6
|