| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity). SUBUNIT: Homodimer or heterodimer. Homodimerization leads to transcriptional repression. Forms high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3. Interacts with NFE2; the interaction results in tranactivation activation. Interacts with CREBBP; the interaction leads to acetylation of the basic region of MAFG and stimulation of NFE2 transcriptional activity through increased DNA binding. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highly expressed in skeletal muscle. Also expressed in heart and brain. PTM: Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2. PTM: Sumoylation at Lys-14 is required for active transcriptional repression (By similarity). SIMILARITY: Belongs to the bZIP family. Maf subfamily. SIMILARITY: Contains 1 bZIP domain. GENE SYNONYMS:MAFG. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 162 AA; 17850 MW; E49F1FBA230F8D30 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
MAFG_HUMAN
|
| biopax3:name |
MAFG,
V-maf musculoaponeurotic fibrosarcoma oncogene homolog G,
hMAF
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| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGLSKEEIVQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKLELDALRSKYEALQTFARTVARSPVAPARGPLAAGLGPLVPGKVAATSVITIVKSKTDARS
|
| biopax3:standardName |
Transcription factor MafG
|