| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. COFACTOR: Binds 1 magnesium ion per monomer (By similarity). SUBUNIT: Monomer. Interacts with REST. SUBCELLULAR LOCATION: Nucleus (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=HYA22B; IsoId=O15194-1; Sequence=Displayed; Name=2; Synonyms=HYA22A; IsoId=O15194-2; Sequence=VSP_011541; TISSUE SPECIFICITY: Expression is restricted to non-neuronal tissues. SIMILARITY: Contains 1 FCP1 homology domain. SEQUENCE CAUTION: Sequence=BAA21667.1; Type=Erroneous initiation; GENE SYNONYMS:CTDSPL C3orf8 NIF1 NIFL SCP3 YA22. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 276 AA; 31129 MW; 5C7B32A1127B0F59 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:16890,
urn:biopax:RelationshipXref:NCBI GENE_10217,
urn:biopax:RelationshipXref:REFSEQ_NP_001008393,
urn:biopax:RelationshipXref:REFSEQ_NP_005799,
urn:biopax:UnificationXref:UNIPROT_O15194,
urn:biopax:UnificationXref:UNIPROT_Q3ZTU0,
urn:biopax:UnificationXref:UNIPROT_Q70KI4,
urn:biopax:UnificationXref:UNIPROT_Q7Z5Q2
|
| biopax3:displayName |
CTDSL_HUMAN
|
| biopax3:name |
3.1.3.16,
CTDSP-like,
CTDSPL,
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3,
NIF-like protein,
NLI-interacting factor 1,
Nuclear LIM interactor-interacting factor 1,
Protein YA22,
RBSP3,
SCP3,
Small C-terminal domain phosphatase 3,
Small CTD phosphatase 3,
hYA22
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MDGPAIITQVTNPKEDEGRLPGAGEKASQCNVSLKKQRSRSILSSFFCCFRDYNVEAPPPSSPSVLPPLVEENGGLQKGDQRQVIPIPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDVYSMLHRLCNR
|
| biopax3:standardName |
CTD small phosphatase-like protein
|