| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. SUBUNIT: Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2. Interacts with FASLG. Interacts with EVL. SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=FYB-120; IsoId=O15117-1; Sequence=Displayed; Name=FYB-130; IsoId=O15117-2; Sequence=VSP_042309; TISSUE SPECIFICITY: Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues. PTM: T-cell receptor ligation leads to increased tyrosine phosphorylation. SIMILARITY: Contains 1 SH3 domain. GENE SYNONYMS:FYB SLAP130. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 783 AA; 85387 MW; 4EE28EF12AA0E457 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:4036,
urn:biopax:RelationshipXref:NCBI GENE_2533,
urn:biopax:RelationshipXref:REFSEQ_NP_001230022,
urn:biopax:RelationshipXref:REFSEQ_NP_001456,
urn:biopax:RelationshipXref:REFSEQ_NP_955367,
urn:biopax:UnificationXref:UNIPROT_A8K2Y8,
urn:biopax:UnificationXref:UNIPROT_E9PBV9,
urn:biopax:UnificationXref:UNIPROT_O00359,
urn:biopax:UnificationXref:UNIPROT_O15117,
urn:biopax:UnificationXref:UNIPROT_Q9NZI9
|
| biopax3:displayName |
FYB_HUMAN
|
| biopax3:name |
ADAP,
Adhesion and degranulation promoting adaptor protein,
FYB,
FYB-120/130,
FYN-T-binding protein,
SLAP-130,
SLP-76-associated phosphoprotein,
p120/p130
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:FYB_HUMAN_1,
urn:biopax:ModificationFeature:FYB_HUMAN_10,
urn:biopax:ModificationFeature:FYB_HUMAN_11,
urn:biopax:ModificationFeature:FYB_HUMAN_12,
urn:biopax:ModificationFeature:FYB_HUMAN_2,
urn:biopax:ModificationFeature:FYB_HUMAN_3,
urn:biopax:ModificationFeature:FYB_HUMAN_4,
urn:biopax:ModificationFeature:FYB_HUMAN_5,
urn:biopax:ModificationFeature:FYB_HUMAN_6,
urn:biopax:ModificationFeature:FYB_HUMAN_7,
urn:biopax:ModificationFeature:FYB_HUMAN_8,
urn:biopax:ModificationFeature:FYB_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MAKYNTGGNPTEDVSVNSRPFRVTGPNSSSGIQARKNLFNNQGNASPPAGPSNVPKFGSPKPPVAVKPSSEEKPDKEPKPPFLKPTGAGQRFGTPASLTTRDPEAKVGFLKPVGPKPINLPKEDSKPTFPWPPGNKPSLHSVNQDHDLKPLGPKSGPTPPTSENEQKQAFPKLTGVKGKFMSASQDLEPKPLFPKPAFGQKPPLSTENSHEDESPMKNVSSSKGSPAPLGVRSKSGPLKPAREDSENKDHAGEISSLPFPGVVLKPAASRGGPGLSKNGEEKKEDRKIDAAKNTFQSKINQEELASGTPPARFPKAPSKLTVGGPWGQSQEKEKGDKNSATPKQKPLPPLFTLGPPPPKPNRPPNVDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPASHPSQPPVPSLPPRNIKPPFDLKSPVNEDNQDGVTHSDGAGNLDEEQDSEGETYEDIEASKEREKKREKEEKKRLELEKKEQKEKEKKEQEIKKKFKLTGPIQVIHLAKACCDVKGGKNELSFKQGEQIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKLKKDSLGAPSRPIEDDQEVYDDVAEQDDISSHSQSGSGGIFPPPPDDDIYDGIEEEDADDGFPAPPKQLDMGDEVYDDVDTSDFPVSSAEMSQGTNVGKAKTEEKDLKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESLEVIQTTDDTKVLCRNEEGKYGYVLRSYLADNDGEIYDDIADGCIYDND
|
| biopax3:standardName |
FYN-binding protein
|