| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42. SUBUNIT: Interacts with CCPG1, which results in specific inhibition of its exchange activity toward RHOA (By similarity). Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4- phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=8; Comment=A number of isoforms are produced. According to EST sequences. Experimental confirmation may be lacking for some isoforms; Name=1; IsoId=O15068-1; Sequence=Displayed; Name=2; IsoId=O15068-2; Sequence=VSP_026120, VSP_026128; Name=3; Synonyms=Ost-II; IsoId=O15068-3; Sequence=VSP_026121, VSP_026128; Name=4; IsoId=O15068-4; Sequence=VSP_026122, VSP_026126, VSP_026127; Name=5; Synonyms=Ost-I; IsoId=O15068-5; Sequence=VSP_026119, VSP_026128; Name=6; IsoId=O15068-6; Sequence=VSP_026123; Name=7; IsoId=O15068-9; Sequence=VSP_026123, VSP_039037; Note=No experimental confirmation available; Name=8; IsoId=O15068-8; Sequence=VSP_026124; DOMAIN: The CRAL-TRIO domain is involved in interaction with inositol phospholipids. DOMAIN: The DH domain is involved in interaction with CCPG1 (By similarity). SIMILARITY: Belongs to the MCF2 family. SIMILARITY: Contains 1 CRAL-TRIO domain. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 SH3 domain. SIMILARITY: Contains 1 spectrin repeat. SEQUENCE CAUTION: Sequence=BAA20817.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAM24069.3; Type=Erroneous gene model prediction; Sequence=CAM24070.1; Type=Erroneous gene model prediction; GENE SYNONYMS:MCF2L KIAA0362. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1137 AA; 128109 MW; B2830890A69C8377 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:14576,
urn:biopax:RelationshipXref:NCBI GENE_23263,
urn:biopax:RelationshipXref:REFSEQ_NP_001106203,
urn:biopax:UnificationXref:UNIPROT_A2A2X1,
urn:biopax:UnificationXref:UNIPROT_A2A2X2,
urn:biopax:UnificationXref:UNIPROT_A2A3G6,
urn:biopax:UnificationXref:UNIPROT_A2A3G8,
urn:biopax:UnificationXref:UNIPROT_B4DIL6,
urn:biopax:UnificationXref:UNIPROT_O15068,
urn:biopax:UnificationXref:UNIPROT_Q5JU56,
urn:biopax:UnificationXref:UNIPROT_Q5VXT1,
urn:biopax:UnificationXref:UNIPROT_Q6ZWD4,
urn:biopax:UnificationXref:UNIPROT_Q765G8,
urn:biopax:UnificationXref:UNIPROT_Q765G9,
urn:biopax:UnificationXref:UNIPROT_Q8N679
|
| biopax3:displayName |
MCF2L_HUMAN
|
| biopax3:name |
DBL's big sister,
MCF2-transforming sequence-like protein,
MCF2L
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MFDCWRFILCKRPGSNSYSSPQRPNEAKKEETDHQIDVSDVIRLVQDTPEATAMATDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSGKAHVPRAHP
|
| biopax3:standardName |
Guanine nucleotide exchange factor DBS
|