Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity). CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. SUBUNIT: Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1 (By similarity). SUBCELLULAR LOCATION: Endomembrane system (By similarity). Note=Associated with membranes (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14986-1; Sequence=Displayed; Name=2; Synonyms=Isoform 1; IsoId=O14986-2; Sequence=VSP_016010, VSP_016011; TISSUE SPECIFICITY: Detected in heart, pancreas, brain, kidney, skeletal muscle and lung. SIMILARITY: Contains 1 PIPK domain. CAUTION: There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha. GENE SYNONYMS:PIP5K1B STM7. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 540 AA; 61036 MW; 7A683794A39A20B6 CRC64;
biopax3:xref
biopax3:displayName
PI51B_HUMAN
biopax3:name
2.7.1.68, PIP5K1-beta, PIP5K1B, PIP5KIbeta, Phosphatidylinositol 4-phosphate 5-kinase type I beta, Protein STM-7, PtdIns(4)P-5-kinase 1 beta, Type I phosphatidylinositol 4-phosphate 5-kinase beta
biopax3:entityFeature
biopax3:organism
biopax3:sequence
MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRSMRMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQKVLYSTAMESIQGPGKSGDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKATSQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVNEHYPHDRPTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLEVQDDNASVLDVYL
biopax3:standardName
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta