| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14933-1; Sequence=Displayed; Name=2; IsoId=O14933-2; Sequence=VSP_037344; TISSUE SPECIFICITY: Present in natural killer cells (at protein level). INDUCTION: By IFNB1/IFN-beta. PTM: ISGylated. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. SEQUENCE CAUTION: Sequence=CAB64566.1; Type=Erroneous initiation; GENE SYNONYMS:UBE2L6 UBCH8. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 153 AA; 17769 MW; D79768775344EFAE CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:12490,
urn:biopax:RelationshipXref:NCBI GENE_9246,
urn:biopax:RelationshipXref:REFSEQ_NP_004214,
urn:biopax:RelationshipXref:REFSEQ_NP_937826,
urn:biopax:UnificationXref:UNIPROT_A6NDM6,
urn:biopax:UnificationXref:UNIPROT_A8MY53,
urn:biopax:UnificationXref:UNIPROT_O14933,
urn:biopax:UnificationXref:UNIPROT_Q8N5D8,
urn:biopax:UnificationXref:UNIPROT_Q9UEZ0
|
| biopax3:displayName |
UB2L6_HUMAN
|
| biopax3:name |
6.3.2.19,
RIG-B,
Retinoic acid-induced gene B protein,
UBE2L6,
UbcH8,
Ubiquitin carrier protein L6,
Ubiquitin-protein ligase L6
|
| biopax3:organism | |
| biopax3:sequence |
MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS
|
| biopax3:standardName |
Ubiquitin/ISG15-conjugating enzyme E2 L6
|