| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. SUBUNIT: Binds formin (By similarity). Binds RNA polymerase II, HD and SF1. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14776-1; Sequence=Displayed; Name=2; IsoId=O14776-2; Sequence=VSP_026933; TISSUE SPECIFICITY: Detected in brain neurons. INDUCTION: Up-regulated in brain tissue from patients with Huntington disease. DOMAIN: The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5). DOMAIN: The WW domains bind Pro-rich domains. SIMILARITY: Contains 6 FF domains. SIMILARITY: Contains 3 WW domains. SEQUENCE CAUTION: Sequence=BAD93147.1; Type=Erroneous initiation; GENE SYNONYMS:TCERG1 CA150 TAF2S. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1098 AA; 123901 MW; 5F0A0C3A07EBF00F CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:15630,
urn:biopax:RelationshipXref:NCBI GENE_10915,
urn:biopax:RelationshipXref:REFSEQ_NP_001035095,
urn:biopax:RelationshipXref:REFSEQ_NP_006697,
urn:biopax:UnificationXref:UNIPROT_O14776,
urn:biopax:UnificationXref:UNIPROT_Q2NKN2,
urn:biopax:UnificationXref:UNIPROT_Q59EA1
|
| biopax3:displayName |
TCRG1_HUMAN
|
| biopax3:name |
TATA box-binding protein-associated factor 2S,
TCERG1,
Transcription factor CA150
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MAERGGDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRGPPPLMRPPPPFGMMRGPPPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPGMMFPPGMPPVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRESAWTKPDGVKVIQQSELTPMLAAQAQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTSSSTPSSTTSTTTTATSVAQTVSTPTTQDQTPSSAVSVATPTVSVSTPAPTATPVQTVPQPHPQTLPPAVPHSVPQPTTAIPAFPPVMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPIVPMIHPQVAIAASPATLAGATAVSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKEKLEEKIKEPIKEPSEEPLPMETEEEDPKEEPIKEIKEEPKEEEMTEEEKAAQKAKPVATAPIPGTPWCVVWTGDERVFFYNPTTRLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKWQFSMSAIKEEQELMEEINEDEPVKAKKRKRDDNKDIDSEKEAAMEAEIKAARERAIVPLEARMKQFKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERREKKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKMKDREALFNEFVAAARKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDLFKQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQHKREEAIQNFKALLSDMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEALTKKKREHFRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDKYITAKADFRTLLKETKFITYRSKKLIQESDQHLKDVEKILQNDKRYLVLDCVPEERRKLIVAYVDDLDRRGPPPPPTASEPTRRSTK
|
| biopax3:standardName |
Transcription elongation regulator 1
|