| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. SUBUNIT: Homotrimer. Can interact with TRADD and RIPK1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=Long; Synonyms=TRICK2B; IsoId=O14763-1; Sequence=Displayed; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=3; IsoId=O14763-3; Sequence=VSP_039125; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=Short; Synonyms=TRICK2A; IsoId=O14763-2; Sequence=VSP_006490; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; TISSUE SPECIFICITY: Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. INDUCTION: Regulated by p53/TP53. DISEASE: Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 3 TNFR-Cys repeats. GENE SYNONYMS:TNFRSF10B DR5 KILLER TRAILR2 TRICK2 ZTNFR9. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 440 AA; 47878 MW; 60358EAF2A835870 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11905,
urn:biopax:RelationshipXref:NCBI GENE_8795,
urn:biopax:RelationshipXref:REFSEQ_NP_003833,
urn:biopax:RelationshipXref:REFSEQ_NP_671716,
urn:biopax:UnificationXref:UNIPROT_O14720,
urn:biopax:UnificationXref:UNIPROT_O14763,
urn:biopax:UnificationXref:UNIPROT_O15508,
urn:biopax:UnificationXref:UNIPROT_O15517,
urn:biopax:UnificationXref:UNIPROT_O15531,
urn:biopax:UnificationXref:UNIPROT_Q6UXM8,
urn:biopax:UnificationXref:UNIPROT_Q7Z360,
urn:biopax:UnificationXref:UNIPROT_Q9BVE0
|
| biopax3:displayName |
TR10B_HUMAN
|
| biopax3:name |
CD262,
Death receptor 5,
TNF-related apoptosis-inducing ligand receptor 2,
TNFRSF10B,
TRAIL receptor 2,
TRAIL-R2
|
| biopax3:organism | |
| biopax3:sequence |
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
|
| biopax3:standardName |
Tumor necrosis factor receptor superfamily member 10B
|