| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. SUBUNIT: Monomer. Oligomerizes upon binding of cytochrome c and dATP. Oligomeric Apaf-1 and pro-caspase-9 bind to each other via their respective NH2-terminal CARD domains and consecutively mature caspase-9 is released from the complex. Pro-caspase-3 is recruited into the Apaf-1-pro-caspase-9 complex via interaction with pro-caspase-9. Interacts with APIP. Interacts (via CARD and NACHT domains) with NAIP/BIRC1 (via NACHT domain). SUBCELLULAR LOCATION: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Apaf-1XL; IsoId=O14727-1; Sequence=Displayed; Name=2; Synonyms=Apaf-1L; IsoId=O14727-2; Sequence=VSP_006759; Name=3; Synonyms=Apaf-1S; IsoId=O14727-3; Sequence=VSP_006759, VSP_006761; Name=4; Synonyms=Apaf-1M; IsoId=O14727-4; Sequence=VSP_006761; Name=5; Synonyms=Apaf-1XS; IsoId=O14727-5; Sequence=VSP_006760, VSP_006761, VSP_006762; Name=6; Synonyms=Apaf-1-ALT; IsoId=O14727-6; Sequence=VSP_008965, VSP_008966; TISSUE SPECIFICITY: Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver. INDUCTION: By E2F and p53/TP53 in apoptotic neurons. DOMAIN: The CARD domain mediates interaction with APIP. SIMILARITY: Contains 1 CARD domain. SIMILARITY: Contains 1 NB-ARC domain. SIMILARITY: Contains 13 WD repeats. SEQUENCE CAUTION: Sequence=AAK28401.1; Type=Frameshift; Positions=108; Sequence=BAA24843.2; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/APAF1ID422.html"; GENE SYNONYMS:APAF1 KIAA0413. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1248 AA; 141840 MW; 0750D05817AC9B3B CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:576,
urn:biopax:RelationshipXref:NCBI GENE_317,
urn:biopax:RelationshipXref:REFSEQ_NP_001151,
urn:biopax:RelationshipXref:REFSEQ_NP_037361,
urn:biopax:RelationshipXref:REFSEQ_NP_863651,
urn:biopax:RelationshipXref:REFSEQ_NP_863658,
urn:biopax:RelationshipXref:REFSEQ_NP_863659,
urn:biopax:UnificationXref:UNIPROT_B2RMX8,
urn:biopax:UnificationXref:UNIPROT_O14727,
urn:biopax:UnificationXref:UNIPROT_O43297,
urn:biopax:UnificationXref:UNIPROT_Q7Z438,
urn:biopax:UnificationXref:UNIPROT_Q9BXZ6,
urn:biopax:UnificationXref:UNIPROT_Q9UBZ5,
urn:biopax:UnificationXref:UNIPROT_Q9UGN8,
urn:biopax:UnificationXref:UNIPROT_Q9UGN9,
urn:biopax:UnificationXref:UNIPROT_Q9UGP0,
urn:biopax:UnificationXref:UNIPROT_Q9UJ58,
urn:biopax:UnificationXref:UNIPROT_Q9UJ59,
urn:biopax:UnificationXref:UNIPROT_Q9UJ60,
urn:biopax:UnificationXref:UNIPROT_Q9UJ61,
urn:biopax:UnificationXref:UNIPROT_Q9UJ62,
urn:biopax:UnificationXref:UNIPROT_Q9UJ63,
urn:biopax:UnificationXref:UNIPROT_Q9UJ64,
urn:biopax:UnificationXref:UNIPROT_Q9UJ65,
urn:biopax:UnificationXref:UNIPROT_Q9UJ66,
urn:biopax:UnificationXref:UNIPROT_Q9UJ67,
urn:biopax:UnificationXref:UNIPROT_Q9UNC9
|
| biopax3:displayName |
APAF_HUMAN
|
| biopax3:name |
APAF-1,
APAF1
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
|
| biopax3:standardName |
Apoptotic protease-activating factor 1
|