| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. CATALYTIC ACTIVITY: Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate. COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity). SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms; Name=PDE2A3; IsoId=O00408-1; Sequence=Displayed; Name=PDE2A1; IsoId=O00408-2; Sequence=Not described; Note=Soluble form; Name=PDE2A2; IsoId=O00408-3; Sequence=Not described; Name=PDE2A4; IsoId=O00408-4; Sequence=VSP_042213; TISSUE SPECIFICITY: Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas. DOMAIN: GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the catalytic activity of the enzyme (By similarity). MISCELLANEOUS: cGMP binds at an allosteric activator site (By similarity). SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily. SIMILARITY: Contains 2 GAF domains. GENE SYNONYMS:PDE2A. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 941 AA; 105717 MW; 9797609B487FD64E CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:8777,
urn:biopax:RelationshipXref:NCBI GENE_5138,
urn:biopax:RelationshipXref:REFSEQ_NP_001137311,
urn:biopax:RelationshipXref:REFSEQ_NP_001139681,
urn:biopax:RelationshipXref:REFSEQ_NP_001230713,
urn:biopax:RelationshipXref:REFSEQ_NP_002590,
urn:biopax:UnificationXref:UNIPROT_E9PGI1,
urn:biopax:UnificationXref:UNIPROT_O00408,
urn:biopax:UnificationXref:UNIPROT_Q5J793
|
| biopax3:displayName |
PDE2A_HUMAN
|
| biopax3:name |
3.1.4.17,
CGS-PDE,
Cyclic GMP-stimulated phosphodiesterase,
PDE2A,
cGSPDE
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
|
| biopax3:standardName |
cGMP-dependent 3',5'-cyclic phosphodiesterase
|