| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. SUBUNIT: Can interact with TRADD and RIPK1. Interacts with ARAP1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 3 TNFR-Cys repeats. GENE SYNONYMS:TNFRSF10A APO2 DR4 TRAILR1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 468 AA; 50089 MW; 7E96619D0BDC0CD4 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11904,
urn:biopax:RelationshipXref:NCBI GENE_8797,
urn:biopax:RelationshipXref:REFSEQ_NP_003835,
urn:biopax:UnificationXref:UNIPROT_A8K5I4,
urn:biopax:UnificationXref:UNIPROT_O00220,
urn:biopax:UnificationXref:UNIPROT_Q53Y72,
urn:biopax:UnificationXref:UNIPROT_Q96E62
|
| biopax3:displayName |
TR10A_HUMAN
|
| biopax3:name |
CD261,
Death receptor 4,
TNF-related apoptosis-inducing ligand receptor 1,
TNFRSF10A,
TRAIL receptor 1,
TRAIL-R1
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE
|
| biopax3:standardName |
Tumor necrosis factor receptor superfamily member 10A
|