Source:http://biocyc.org/biopax/biopax-level3SmallMolecule137759
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:cellularLocation | |
| biopax3:comment |
<i>N</i>-acetylneuraminate, the most ubiquitous species amongst the sialic acids, is widely distributed in the animal kingdom as a component of oligosaccharides, glycoproteins, and glycolipids. <i>N</i>-acetylneuraminate carries out various biological functions by acting as receptors for microorganisms, viruses, toxins, and hormones, by masking receptors, and by regulation of the immune system. N-acetylneuraminic acid is the predominant form of sialic acid present in humans. It can be found as a terminal sugar on a wide range of surface glycoconjugates |CITS: [11841250]|. This acid is present in sialoconjugates as the α-anomer |CITS: [18063573]|. A number of bacteria that can colonize humans make use of N-acetylneuraminic acid as a nutrient source. In addition, some pathogens such as Haemophilus influenzae use for sialic acid in an immune evasion mechanism by adding N-acetylneuraminic acid to their lipopolysaccharide |CITS: [12180977][10447878]|, which provides increased survival in human serum. Most of these organisms are not capable of synthesizing N-acetylneuraminic acid and import it into the cells |CITS: [16262798]| after conversion (either spontaneous or enzymatic) to the β-anomer |CITS: [18063573]| .
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| biopax3:dataSource | |
| biopax3:displayName |
N-acetylneuraminate
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| biopax3:name |
5-acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid,
5-acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid,
<i>N</i>-acetylneuraminate,
<i>N</i>-acetylneuraminic acid,
NANA,
Neu5Ac,
O-sialic acid,
sialate,
sialic acid
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| biopax3:entityReference | |
| biopax3:standardName |
N-acetylneuraminate
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