| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:cellularLocation | |
| biopax3:comment |
<i>CYP11B2</i> encodes a member of the cytochrome P450 superfamily of heme containing membrane associated enzymes. These proteins function as monooxygenases utilizing NADPH for the reduction of molecular oxygen via a membrane bound electron transfer system. CYP11B2 localizes to the mitochondrial inner membrane and catalyzes the conversion of 11-deoxycortisone to aldosterone in three distinct reactions at a single active site. |CITS: [1741400]|. In these reactions the electrons from NADPH are transferred to a flavin containing protein, ferredoxin reductase and subsequently to ferredoxin (a non-heme iron-sulfur protein), to CYP11B2 and finally to activate the oxygen substrate |CITS: [9029726]|. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.
|
| biopax3:xref |
http://identifiers.org/pubmed/11841224,
http://identifiers.org/pubmed/11856349,
http://identifiers.org/pubmed/11903322,
http://identifiers.org/pubmed/11932209,
http://identifiers.org/pubmed/11967817,
http://identifiers.org/pubmed/12065207,
http://identifiers.org/pubmed/12133420,
http://identifiers.org/pubmed/12161536,
http://identifiers.org/pubmed/12172317,
http://identifiers.org/pubmed/12193581,
http://identifiers.org/pubmed/12195120,
http://identifiers.org/pubmed/12213905,
http://identifiers.org/pubmed/12376254,
http://identifiers.org/pubmed/12391843,
http://identifiers.org/pubmed/1303253,
http://identifiers.org/pubmed/1518866,
http://identifiers.org/pubmed/1594605,
http://identifiers.org/pubmed/1741400,
http://identifiers.org/pubmed/1775135,
http://identifiers.org/pubmed/2256920,
http://identifiers.org/pubmed/2592361,
http://identifiers.org/pubmed/7792802,
http://identifiers.org/pubmed/8372604
|
| biopax3:dataSource | |
| biopax3:displayName |
ALDOS
|
| biopax3:name |
Aldosterone synthase,
Aldosterone-synthesizing enzyme,
CYPXIB2,
P-450Aldo,
P-450C18,
Steroid 18-hydroxylase,
cytochrome P450 11B, mitochondrial
|
| biopax3:entityReference | |
| biopax3:standardName |
cyp11B2
|