| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:cellularLocation | |
| biopax3:comment |
1-acyl-sn-glycerol-3-phosphate acyltransferases catalyzes the conversion of lysophosphatidate (LPA) compounds to phosphatidate (PA) compouds. LPA and PA are two types of phospholipids that are involved in signal transduction and in lipid biosynthesis in cells. Humans have at least five isoforms of the enzyme, encoded by |FRAME: HS09762|, |FRAME: HS09990|, |FRAME: HS08470|, |FRAME: HS00452| and |FRAME: HS08034|. Although they catalyze the same biochemical reaction, they differ in their relative function, tissue expression and regulation . The human |FRAME: HS09762| and |FRAME: HS09990| have been studied in some detail. In mice. mAGPAT1 and mAGPAT3 were ubiquitously expressed in most tissues, whereas mAGPAT2, mAGPAT4 and mAGPAT5 were expressed in a tissue-specific manner |CITS: [15367102]|. The |FRAME: HS09762| gene, encoding the |FRAME: HS09762-MONOMER| enzyme, is located in the class III region of the human major histocompatibility complex |CITS: [9461603]|. Alternative splicing results in two transcript variants encoding the same protein. The |FRAME: HS09762| gene has been cloned and sequenced multiple times |CITS: [9212163][9291118]|. The enzyme has been expressed in the baculovirus system and in mammalian cells. In addition, cell extracts from insect cells overexpressing the gene were analyzed using different acyl acceptors and acyl donors as substrates |CITS: [9461603]|. The enzyme is localized to the endoplasmic reticulum membrane |CITS: [9461603]|. The gene was also expressed in E. coli and complemented a |FRAME: EG11377| defficiency |CITS: [9212163][9291118]|. |FRAME: HS09762-MONOMER| mRNA is uniformly expressed throughout most tissues, with the highest level found in skeletal muscle |CITS: [11487472]|.
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| biopax3:dataSource | |
| biopax3:displayName |
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
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| biopax3:name |
1-AGP acyltransferase 1,
1-AGPAT 1,
1-acylglycerol-3-phosphate O-acyltransferase 1,
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha),
lysophosphatidic acid acyltransferase alpha,
lysophospholipid acyltransferase
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| biopax3:entityReference | |
| biopax3:standardName |
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
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