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| biopax3:comment |
<b>General Background</b> The regulatory subunits of the PI 3-kinases influence the subcellular location, enzymatic activity, and stability of the associated catalytic subunit. The family of mammalian regulatory subunits of PI 3-kinase has been slowly expanding, and currently includes six members. Three of these bind to class IA catalytic subunits (known as |FRAME: HS04527-MONOMER "p110α"|, |FRAME: HS00644-MONOMER "p110β"| and |FRAME: ENSG00000171608-MONOMER "p110δ"|) and are activated by receptor tyrosine kinases. Two others bind to the class IB catalytic unit |FRAME: HS02818-MONOMER "p110γ"|, and are activated by G protein-coupled receptors (GPCRs), and one binds to the class III catalytic |FRAME: HS01275-MONOMER "p100"| subunit. The first member of the group was |FRAME: ENSG00000145675-MONOMER "p85α"| (|FRAME: HS07270|), which contains an N-terminal src-homology 3 (SH3) domain and two src-homology 2 (SH2) domains. Other members were discovered based on homology. |FRAME: ENSG00000105647-MONOMER "p85β"| (|FRAME: HS02779|) consists of similar structural domains to p85α but its amino acid sequence is only 62% identical. |FRAME: ENSG00000117461-MONOMER "p55γ"| (|FRAME: HS04135|) is composed of a unique 30-residue amino terminus followed by a proline-rich motif and two SH2 domains with significant sequence identify to those in p85. It contains no SH3 domain. Two types of regulatory subunits interact only with the class IB |FRAME: HS02818-MONOMER "p110γ"| catalytic subunit. They consist of |FRAME: HS13887-MONOMER "p101"| (encoded by |FRAME: HS13887|) and |FRAME: ENSG00000174083-MONOMER "p87"| (|FRAME: HS16294|) |CITS: [16476736]|. Both of these subunits bind to both p110γ and heterodimeric GTPase βγ subunits and mediate activation of p110γ downstream of G protein-coupled receptors. The last known regulatory subunit is |FRAME: HS03788-MONOMER "p150"|, encoded by |FRAME: HS03788|, which associates only with the class III |FRAME: HS01275-MONOMER "p100"| catalytic subunit. <b>About This Protein</b> The |FRAME: HS02779| gene has been mapped to chromosome 19q13.2-q13.4 |CITS: [1314371]|. A oncogenic fusion has been demonstrated between this gene and HUMORF8, a putative deubiquitinating enzyme |CITS: [9582025]|.
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| biopax3:displayName |
phosphatidylinositol 3-kinase regulatory subunit p85β
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| biopax3:name |
PI3-kinase p85 subunit beta,
PtdIns-3-kinase p85-beta,
phosphatidylinositol 3-kinase regulatory beta subunit,
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta),
phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
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| biopax3:entityReference | |
| biopax3:standardName |
phosphatidylinositol 3-kinase regulatory subunit p85β
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