| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Phospholipase C enzymes (PLCs) catalyze the cleavage of |FRAME: PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA "phosphatidylinositol-4,5-bisphosphate"| and result in the release of |FRAME: DIACYLGLYCEROL "1,2-diacylglycerol"| (DAG) and |FRAME: INOSITOL-1-4-5-TRISPHOSPHATE| (IP3 ) from membranes in response to receptor activation. This in turn results in activation of protein kinase C and the release of |FRAME: CA+2| from intracellular stores. Several distinct classes of PLCs that specifically react with phosphatidylinositols are known to exist in mammals. They have ben named the β γ. δ, ε, ζ and η classes |CITS:[11395409][12117804][17895620]|. As of 2007, thirteen isoforms have been described |CITS: [17895620]|. |FRAME: HS06773-MONOMER "Phospholipase Cγ2"| has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B-lymphocytes |CITS: [12049640 ]|. A cDNA encoding |FRAME: HS06773-MONOMER| has been cloned and expressed in E. coli, and the activity of the recombinant protein has been confirmed |CITS:[2849563][12359094]|. In a similar experiment the recombinant protein has been purified |CITS: [12181444]|. The recombinant enzyme was |FRAME: CA+2|-dependent with optimal activity in the range of 1 to 10 μM. The enzyme is activated by phosphorylation of tyrosines 753 and 759 residues |CITS: [12181444 ]|. The |FRAME: HS06773| gene has been mapped to chromosome 16 |CITS: [7835906]|.
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| biopax3:dataSource | |
| biopax3:displayName |
phospholipase Cγ2
|
| biopax3:name |
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2
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| biopax3:entityReference | |
| biopax3:standardName |
phospholipase Cγ2
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