biopax-level3Pathway177606

<b>General Background</b> Phospholipids are important membrane components. Most of the phospholipids belong to the category of phosphoglycerides. The simplest phosphoglycerides, which are known as phosphatidates, are composed of a glycerol molecule attached to two fatty acids and one phosphate group. The carboxyl group of each fatty acid is esterified to the hydroxyl groups on carbon-1 and carbon-2 of the glycerol molecule, while the phosphate group is attached to carbon-3 by an ester link. Phosphatidates are precursors for many phosphoglycerides including |FRAME: Phosphatidylinositols|, |FRAME: L-1-PHOSPHATIDYL-SERINE|, |FRAME: L-1-PHOSPHATIDYL-ETHANOLAMINE|, and |FRAME: CARDIOLIPIN|. As part of the synthesis of phosphoglycerides, either the phosphatidate or the modifying compound need to be activated by |FRAME:CTP|. In some cases, the modifying compound is activated, as in the case of |FRAME: CHOLINE| and |FRAME: ETHANOL-AMINE|, which form |FRAME: CDP-CHOLINE| and |FRAME: CDP-ETHANOLAMINE|, respectively. However, in the case of other compounds, such as |FRAME: SER| and |FRAME: MYO-INOSITOL|, the phosphatidate is activated first, forming |FRAME: CDPDIACYLGLYCEROL|, which then reacts with the modifying compound to form the phosphoglyceride. <b>About This Pathway</b> This pathway describes the biosynthesis of |FRAME: CDPDIACYLGLYCEROL|. In this pathway the production of the intermediate |FRAME: ACYL-SN-GLYCEROL-3P| is catalyzed by the membrane-bound enzyme |FRAME: GLYCEROL-3-P-ACYLTRANSFER-MONOMER|.

http://biocyc.org/biopax/biopax-level3Provenance125051, urn:biopax:Provenance:humancyc_16

CDP-diacylglycerol biosynthesis

http://biocyc.org/biopax/biopax-level3BiochemicalReaction152243, http://biocyc.org/biopax/biopax-level3BiochemicalReaction162301, http://biocyc.org/biopax/biopax-level3BiochemicalReaction162366, http://biocyc.org/biopax/biopax-level3BiochemicalReaction172973, http://biocyc.org/biopax/biopax-level3Catalysis152245, http://biocyc.org/biopax/biopax-level3Catalysis152255, http://biocyc.org/biopax/biopax-level3Catalysis162303, http://biocyc.org/biopax/biopax-level3Catalysis162312, http://biocyc.org/biopax/biopax-level3Catalysis162319, http://biocyc.org/biopax/biopax-level3Catalysis162326, http://biocyc.org/biopax/biopax-level3Catalysis162336, http://biocyc.org/biopax/biopax-level3Catalysis162342, http://biocyc.org/biopax/biopax-level3Catalysis162348, http://biocyc.org/biopax/biopax-level3Catalysis162354, http://biocyc.org/biopax/biopax-level3Catalysis162360, http://biocyc.org/biopax/biopax-level3Catalysis162368, http://biocyc.org/biopax/biopax-level3Catalysis162374, http://biocyc.org/biopax/biopax-level3Catalysis162381, http://biocyc.org/biopax/biopax-level3Catalysis162389, http://biocyc.org/biopax/biopax-level3Catalysis162395, http://biocyc.org/biopax/biopax-level3Catalysis162401, http://biocyc.org/biopax/biopax-level3Catalysis162406

CDP-diacylglycerol biosynthesis I