| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Adenosine nucleotides can be synthesized <i>de novo</i>. In that route |FRAME: AMP| (AMP) is synthesized via |FRAME: IMP| (IMP) and |FRAME: ADENYLOSUCC| , which is converted to AMP by the action of |FRAME: ASL-MONOMER| (see |FRAME: PWY-6126|). Note that the free base |FRAME: ADENINE| or the ribonucleoside |FRAME: ADENOSINE| are not produced via the <i>de novo</i> pathway. Many organisms can also recycle adenosine nucleotides by a combination of degradation and salvage pathways. The degradation pathways are responsible for the conversion of the nucleotides to the nucleoside (|FRAME: ADENOSINE|) and free base form (|FRAME: ADENINE|), and further degradation to compounds that can be catabolized to basic building blocks (for example, see |FRAME: SALVADEHYPOX-PWY|). However, both |FRAME: ADENOSINE| and |FRAME: ADENINE| can be salvaged by certain enzymes, and be converted back to nucleotide form. The enzyme |FRAME: DEOD-CPLX "purine phosphorylase (DeoD)"| (EC 2.4.2.1) cleaves |FRAME: ADENOSINE| to |FRAME: ADENINE| and |FRAME: RIBOSE-1P|, while a second enzyme, such as |FRAME: ADENPRIBOSYLTRAN-CPLX|, can utilize |FRAME: PRPP| to convert the free base to the mononucleotide |FRAME: AMP|. Other routes from |FRAME: ADENOSINE| to |FRAME: AMP| are described in |FRAME: PWY-6605| and |FRAME: PWY-6619|. Either of these routes enables the organism to salvage the degradation products of adenosine nucleotides, and recycle them back to nucleotide form.
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
adenine and adenosine salvage I
|
| biopax3:name |
adenosine nucleosides salvage I,
purine salvage,
salvage pathway of adenosine nucleosides
|
| biopax3:evidence | |
| biopax3:pathwayComponent | |
| biopax3:pathwayOrder | |
| biopax3:standardName |
adenine and adenosine salvage I
|