| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
|FRAME: CPLX-7838| catalyzes the condensation of |FRAME:ACETYL-COA| with |FRAME: ACETOACETYL-COA| to form |FRAME: 3-HYDROXY-3-METHYL-GLUTARYL-COA|, an early stage in the synthesis of |FRAME: MEVALONATE|, a precursor of cholesterol. The |FRAME: HS03634| gene has been cloned and sequenced |CITS: [1358203]|. The gene was expressed in E. coli, and the recombinant protein was purified and characterized |CITS: [7913309]|. The enzyme is a homodimer of 120 kDa. Catalysis proceeds by formation of a covalent acetyl-enzyme intermediate. Kinetic data suggest that the two substrates (|FRAME:ACETYL-COA| and |FRAME: ACETOACETYL-COA|) compete for binding to the same site.
|
| biopax3:component | |
| biopax3:componentStoichiome... | |
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
hydroxymethylglutaryl-CoA synthase
|
| biopax3:standardName |
hydroxymethylglutaryl-CoA synthase
|