Source:http://biocyc.org/biopax/biopax-level3Catalysis163779
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:controlType |
ACTIVATION
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| biopax3:controlled | |
| biopax3:comment |
Catechol <i>O</i>-methyltransferase catalyzes the transfer of the methyl group from <i>S</i>-adenosyl-L-methionine to one of the hydroxyl groups of a catechol, in the presence of Mg<sup>2+</sup>. Its physiological function is to inactivate biologically active, or toxic catechols. The membrane-bound isoform has lower K<sub>m</sub> values for catechol substrates than the soluble form. The K<sub>m</sub> for dopamine was approximately 100-fold lower for the membrane-bound form than the soluble form. The ratio of the products 3-methoxytyramine to 4-methoxytyramine was 8.8. The enzyme showed both substrate and product inhibition. Triton X-100 inhibited the membrane-bound, but not the soluble form of the enzyme. |CITS: [7082642] [6693904] [1847521] [7703232]|.
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| biopax3:xref | |
| biopax3:controller | |
| biopax3:dataSource | |
| biopax3:displayName |
catechol O-methyltransferase
|
| biopax3:name |
catechol <i>O</i>-methyltransferase
|
| biopax3:evidence | |
| biopax3:standardName |
catechol O-methyltransferase
|