Source:HTTP://PATHWAYCOMMONS.ORG/PSI2BP#_1922895480834249552
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Apoptosis - Interactions involving proteins with a function related to apoptosis dataset MI:0875,
Cancer - Interactions investigated in the context of cancer dataset MI:0875,
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes,
Chromatin - Epigenetic interactions resulting in chromatin modulation dataset MI:0875,
For each protein identified in an immunoprecipitation experiment against one of the bait proteins (7,000 unique bait/protein pairs) enrichment was normalized to values between 0 and 1. The C-score for the unique bait/protein combinations observed in compound profiling and immunoprecipitation experiments was calculated as the sum of squares of the average normalized pIC50 and the normalized enrichment values. The resulting value was dubbed C-score and it scales from 0 to 2. The subset of high confidence interactions was then determined (FDR < 0.05: C-score > 1.14; FDR < 0.15: C-score >1.0 and max(c-score) > 1.2) confidence-mapping MI:0622,
Only protein-protein interactions full coverage MI:0957,
Typically, four IP reactions, which were subsequently combined in a single iTRAQ sample for MS/MS analysis, were done in parallel, two with different antibodies directed against the same (or different) antigen(s) and two 'mock IP' samples. exp-modification MI:0627,
imex curation MI:0959,
imex curation curation depth MI:0955,
marcus.bantscheff@cellzome.com, gerard.drewes@cellzome.com contact-email MI:0634
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