Source:HTTP://PATHWAYCOMMONS.ORG/PSI2BP#_1889014400107787732
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| biopax3:comment |
2009 publication year MI:0886,
Apoptosis - Interactions involving proteins with a function related to apoptosis dataset MI:0875,
Cancer - Interactions investigated in the context of cancer dataset MI:0875,
Huang S.M., Mishina Y.M., Liu S., Cheung A., Stegmeier F., Michaud G.A., Charlat O., Wiellette E., Zhang Y., Wiessner S., Hild M., Shi X., Wilson C.J., Mickanin C., Myer V., Fazal A., Tomlinson R., Serluca F., Shao W., Cheng H., Shultz M., Rau C., Schirle M., Schlegl J., Ghidelli S., Fawell S., Lu C., Curtis D., Kirschner M.W., Lengauer C., Finan P.M., Tallarico J.A., Bouwmeester T., Porter J.A., Bauer A., Cong F. author-list MI:0636,
LDW639 (a bioactive analogue of XAV939, coupled to Sepharose beads) was used to affinity capture cellular proteins from HEK293 cell lysates pre incubated with an excess amount of XAV939, or the inactive analogue LDW643, or DMSO. Bound material was differentially iTRAQ labelled and LS-MS/MS carried out. Specific binding of proteins to LDW639 was competed with by soluble XAV939, but not the inactive LDW643. Results shown here are the 18 proteins with >3 spectrum matches to unique peptides. exp-modification MI:0627,
Nature (0028-0836) journal MI:0885,
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.,
feng.cong@novartis.com contact-email MI:0634,
imex curation curation depth MI:0955
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