| http://www.reactome.org/bio... | biopax3:comment | RIP1 is recruited to the activated TLR receptor by binding to TIKAM1(TRIF) via its RHIM motif, followed by its polyubiquitination.<p>Polyubiquitination is possibly mediated by TRAF6 that is also recruited to the TIKAM1.<p>Upon TLR stimulation, TRIF may interact with RIP1, promoting apoptosis by recruiting FADD and activating caspase-8 (Ma et al 2005, Kaiser et al 2005). | lld:biopax3 |
