| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
RIP1 is recruited to the activated TLR receptor by binding to TIKAM1(TRIF) via its RHIM motif, followed by its polyubiquitination.<p>Polyubiquitination is possibly mediated by TRAF6 that is also recruited to the TIKAM1.<p>Upon TLR stimulation, TRIF may interact with RIP1, promoting apoptosis by recruiting FADD and activating caspase-8 (Ma et al 2005, Kaiser et al 2005).
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