http://purl.uniprot.org/cit... | rdf:type | uniprot:Journal_Citation | lld:uniprot |
http://purl.uniprot.org/cit... | rdfs:comment | Staphyllococcus aureus-induced infections often result in high mortality and permanent joint destruction, despite treatment with antibiotics. IL-10 is typically regarded as an anti-inflammatory cytokine because it promotes a T helper cell type 2 response, and subsequently down-regulates cell mediated immune functions. To investigate the role of IL-10 in S. aureus-induced arthritis and sepsis, Balb/c mice, intact or defective with respect to IL-10 gene were intravenously inoculated with bacteria. IL-10-/-mice develop a more frequent and destructive arthritis compared to their congeneic controls. The mechanisms regulating such outcome may be due not only to the anti-inflammatory properties of IL-10 but also, directly or indirectly, to antibacterial features of this molecule. Indeed, inoculation of staphylococci to IL-10-/-mice resulted in higher bacterial load in blood and kidneys compared to congeneic controls. Altogether our data indicate that IL-10 is essential for efficient elimination of bacteria and thereby for protection against septic arthritis. | lld:uniprot |
http://purl.uniprot.org/cit... | skos:exactMatch | http://purl.uniprot.org/pub... | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:name | Clin. Exp. Immunol. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Tarkowski A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Hultgren O.H. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Gjertsson I. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:date | 2002 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:pages | 409-414 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:title | Interleukin-10 ameliorates the outcome of Staphylococcus aureus arthritis by promoting bacterial clearance. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:volume | 130 | lld:uniprot |
http://purl.uniprot.org/cit... | dc-term:identifier | doi:10.1046/j.1365-2249.2002.01999.x | lld:uniprot |
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http://linkedlifedata.com/r... | uniprot:source | http://purl.uniprot.org/cit... | lld:uniprot |