Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity).
| Subject | Predicate | Object | Context |
|---|---|---|---|
| http://purl.uniprot.org/SHA... | rdf:type | uniprot:Function_Annotation | lld:uniprot |
| http://purl.uniprot.org/SHA... | rdfs:comment | Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity). | lld:uniprot |
| uniprot-protein:Q6AYT2 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
| uniprot-protein:Q5EAD3 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |