O-glycosylation at Thr-440 in the SET domain by OGT is essential for the histone methyltransferase and the coactivator activity toward RARA in granulopoiesis (By similarity). The absence of Thr-440 glycosylation in assays done in vitro may explain why PubMed:18952892 and PubMed:19264965 did not detected any histone methyltransferase activity for this protein.
Subject | Predicate | Object | Context |
---|---|---|---|
http://purl.uniprot.org/SHA... | rdf:type | uniprot:PTM_Annotation | lld:uniprot |
http://purl.uniprot.org/SHA... | rdfs:comment | O-glycosylation at Thr-440 in the SET domain by OGT is essential for the histone methyltransferase and the coactivator activity toward RARA in granulopoiesis (By similarity). The absence of Thr-440 glycosylation in assays done in vitro may explain why PubMed:18952892 and PubMed:19264965 did not detected any histone methyltransferase activity for this protein. | lld:uniprot |
uniprot-protein:Q3UG20 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |