| family:PF07263.6 | rdf:type | pfam:Family | lld:pfam |
| family:PF07263.6 | family:comment | This family consists of several mammalian dentin matrix protein1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21 [1]. DMP1 is a bone and teeth specific protein initially identified from mineralised dentin. DMP1 is primarily localised in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralised matrix formation extracellularly, at later stages of osteoblast maturation [2]. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown [3]. | lld:pfam |
| family:PF07263.6 | family:id | DMP1 | lld:pfam |
| family:PF07263.6 | family:description | Dentin matrix protein 1 (DMP1) | lld:pfam |
| family:PF07263.6 | family:authorList | Moxon SJ | lld:pfam |
| family:PF07263.6 | family:familyType | Family | lld:pfam |
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| family:PF07263.6 | family:pubmed | pubmed-article:12929940 | lld:pfam |
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