Source:http://linkedlifedata.com/resource/pfam/family/PF07263.6
| Predicate | Object |
|---|---|
| rdf:type | |
| family:comment |
This family consists of several mammalian dentin matrix protein1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21 [1]. DMP1 is a bone and teeth specific protein initially identified from mineralised dentin. DMP1 is primarily localised in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralised matrix formation extracellularly, at later stages of osteoblast maturation [2]. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown [3].
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| family:id |
DMP1
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| family:description |
Dentin matrix protein 1 (DMP1)
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| family:authorList |
Moxon SJ
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| family:familyType |
Family
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| family:dbReference | |
| family:pubmed | |
| family:protein |