Linked Life Data

P56937

Source:http://identifiers.org/uniprot/P56937

Statements in which the resource exists.
SubjectPredicateObjectContext
http://identifiers.org/unip...rdf:typebiopax3:ProteinReferencelld:biopax3
http://identifiers.org/unip...biopax3:commentSEQUENCE 341 AA; 38206 MW; FE4892B2602F549B CRC64;lld:biopax3
http://identifiers.org/unip...biopax3:commentFUNCTION: Responsible for the reduction of the keto group on the C-3 of sterols. CATALYTIC ACTIVITY: 4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NADP(+) = 4-alpha-methyl-5-alpha-cholest-7-en-3-one + NADPH. CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H. PATHWAY: Steroid biosynthesis; estrogen biosynthesis. PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6. SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P56937-1; Sequence=Displayed; Name=2; IsoId=P56937-2; Sequence=VSP_006029; Name=3; IsoId=P56937-3; Sequence=VSP_012766; TISSUE SPECIFICITY: Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells. PTM: Phosphorylated. SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. GENE SYNONYMS:HSD17B7. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biopax3
http://identifiers.org/unip...biopax3:xrefurn:biopax:UnificationXref:...lld:biopax3
http://identifiers.org/unip...biopax3:xrefurn:biopax:RelationshipXref...lld:biopax3
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http://identifiers.org/unip...biopax3:xrefurn:biopax:RelationshipXref...lld:biopax3
http://identifiers.org/unip...biopax3:xrefurn:biopax:UnificationXref:...lld:biopax3
http://identifiers.org/unip...biopax3:xrefurn:biopax:UnificationXref:...lld:biopax3
http://identifiers.org/unip...biopax3:xrefurn:biopax:UnificationXref:...lld:biopax3
http://identifiers.org/unip...biopax3:displayNameDHB7_HUMANlld:biopax3
http://identifiers.org/unip...biopax3:name1.1.1.62lld:biopax3
http://identifiers.org/unip...biopax3:name1.1.1.270lld:biopax3
http://identifiers.org/unip...biopax3:name17-beta-hydroxysteroid dehydrogenase 7lld:biopax3
http://identifiers.org/unip...biopax3:nameHSD17B7lld:biopax3
http://identifiers.org/unip...biopax3:nameEstradiol 17-beta-dehydrogenase 7lld:biopax3
http://identifiers.org/unip...biopax3:name17-beta-HSD 7lld:biopax3
http://identifiers.org/unip...biopax3:entityFeatureurn:biopax:ModificationFeat...lld:biopax3
http://identifiers.org/unip...biopax3:organismhttp://identifiers.org/taxo...lld:biopax3
http://identifiers.org/unip...biopax3:sequenceMRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCLlld:biopax3
http://identifiers.org/unip...biopax3:standardName3-keto-steroid reductaselld:biopax3
http://www.reactome.org/bio...biopax3:entityReferencehttp://identifiers.org/unip...lld:biopax3
http://pid.nci.nih.gov/biop...biopax3:entityReferencehttp://identifiers.org/unip...lld:biopax3
http://biocyc.org/biopax/bi...biopax3:entityReferencehttp://identifiers.org/unip...lld:biopax3
http://www.reactome.org/bio...biopax3:entityReferencehttp://identifiers.org/unip...lld:biopax3