| http://biocyc.org/biopax/bi... | rdf:type | biopax3:Protein | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:cellularLocation | http://identifiers.org/obo... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:comment | <i>CYP11B2</i> encodes a member of the cytochrome P450 superfamily of heme containing membrane associated enzymes. These proteins function as monooxygenases utilizing NADPH for the reduction of molecular oxygen via a membrane bound electron transfer system. CYP11B2 localizes to the mitochondrial inner membrane and catalyzes the conversion of 11-deoxycortisone to aldosterone in three distinct reactions at a single active site. |CITS: [1741400]|. In these reactions the electrons from NADPH are transferred to a flavin containing protein, ferredoxin reductase and subsequently to ferredoxin (a non-heme iron-sulfur protein), to CYP11B2 and finally to activate the oxygen substrate |CITS: [9029726]|. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:dataSource | urn:biopax:Provenance:human... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:dataSource | http://biocyc.org/biopax/bi... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:displayName | ALDOS | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:name | P-450C18 | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:name | P-450Aldo | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:name | CYPXIB2 | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:name | Aldosterone synthase | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:name | cytochrome P450 11B, mitochondrial | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:name | Aldosterone-synthesizing enzyme | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:name | Steroid 18-hydroxylase | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:entityReference | http://identifiers.org/unip... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:standardName | cyp11B2 | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:controller | http://biocyc.org/biopax/bi... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:controller | http://biocyc.org/biopax/bi... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:controller | http://biocyc.org/biopax/bi... | lld:biopax3 |
