Source:http://linkedlifedata.com/resource/umls/id/C1833840
NCI: A fusion gene that results from a cryptic rearrangement of chromosome 1q that fuses the 5' portion of the NTRK1 gene to the 3' end of the TPM3. This rearrangement is associated with papillary thyroid carcinoma.,NCI: A fusion gene (~2.3 kb) that results from a cryptic rearrangement of chromosome 1q that fuses most of the coding sequence for the TPM3 gene to the 3' portion of the NTRK1 gene. This rearrangement is associated with papillary thyroid carcinoma.,NCI: Human Oncogene TRK is a mutated variant of NTRK1 Gene (INSR family), which encodes two alternative type I membrane protein Neurotrophic Tyrosine Kinase Receptor Type 1 with similar biological properties. TRKA-II is primarily expressed in neurons; TRKA-I is non-neuronal. NTRK1 exists as low affinity monomeric and high affinity dimeric structures, with TRKA, TRKB, or TRKC, that bind neurotrophins. TRKA, TRKB, and TRKC partners are preferred by NGF, NTF5 and BDNF, and NTF3, respectively. Ligands stimulate autophosphorylation of TRK. NTRK1 defects caus